Name: Raltegravir (MK-0518)
Descriptions:
Product Number LS50036
CAS Number 518048-05-0
Product Name Raltegravir (MK-0518)
Molecular Formula C20H21FN6O5
Formula Weight 444.42
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Raltegravir (MK-0518, Isentress) is a potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM, respectivly.
CAS No. 518048-05-0, 1292804-07-9 (sodium salt), 871038-72-1 (potassium salt)
Synonyms Isentress
Name: Rapamycin (Sirolimus)
Descriptions:
Product Number LS50035
CAS Number 53123-88-9
Product Name Rapamycin (Sirolimus)
Molecular Formula C51H79NO13
Formula Weight 914.17
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Rapamycin (Sirolimus, AY-22989, WY-090217) is a specific mTOR inhibitor with IC50 of ~0.1 nM.
CAS No. 53123-88-9, 1179372-35-0, 1189166-54-8, 1233221-34-5, 1353039-01-6
Name: Ritonavir
Descriptions:
Product Number LS50034
CAS Number 155213-67-5
Product Name Ritonavir
Molecular Formula C37H48N6O5S2
Formula Weight 720.94
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Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS. It is now rarely used for its own antiviral activity, but remains widely used as a booster of other protease inhibitors. More specifically, ritonavir is used to inhibit a particular liver enzyme that normally metabolizes protease inhibitors, cytochrome P450-3A4 (CYP3A4). The drug’s molecular structure inhibits CYP3A4, so a low dose can be used to enhance other protease inhibitors. This discovery has drastically reduced the adverse effects and improved the efficacy of PI’s and HAART.
Synonyms Norvir, Norvir Softgel
Name: Saxagliptin (BMS-477118,Onglyza)
Descriptions:
Product Number LS50032
CAS Number 361442-04-8
Product Name Saxagliptin (BMS-477118,Onglyza)
Molecular Formula C18H25N3O2
Formula Weight 315.41
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Saxagliptin (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.
CAS No. 361442-04-8, 709031-78-7 (HCl), 361442-05-9 (TFA)
Name: RU 58841 (RU58841)
Descriptions:
Product Number LS50033
CAS Number 154992-24-2
Product Name RU 58841 (RU58841)
Molecular Formula C17H18F3N3O3
Formula Weight 369.34
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Name: SGX-523
Descriptions:
Product Number LS50031
CAS Number 1022150-57-7
Product Name SGX-523
Molecular Formula C18H13N7S
Formula Weight 359.41
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SGX-523 is a selective Met inhibitor with IC50 of 4 nM.
Name: SNS-032 (BMS-387032)
Descriptions:
Product Number LS50030
CAS Number 345627-80-7
Product Name SNS-032 (BMS-387032)
Molecular Formula C17H24N4O2S2
Formula Weight 380.53
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SNS-032 is a novel, potent and selective CDK inhibitor of CDK2, CDK7 and CDK9 with IC50 of 38 nM, 62 nM and 4 nM, respectively.
CAS No. 345627-80-7, 345627-90-9 (HCl)
Name: SU-11274
Descriptions:
Product Number LS50029
CAS Number 658084-23-2
Product Name SU-11274
Molecular Formula C28H30CIN5O4S
Formula Weight 568.09
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SU11274 is a selective Met inhibitor with IC50 of 10 nM.
Synonyms PKI-SU11274
Name: SU-5402 (SU5402)
Descriptions:
Product Number LS50028
CAS Number 215543-92-3
Product Name SU-5402 (SU5402)
Molecular Formula C17H16N2O3
Formula Weight 296.32
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Name: TSU-68 (SU6668, Orantinib)
Descriptions:
Product Number LS50027
CAS Number 252916-29-3
Product Name TSU-68 (SU6668, Orantinib)
Molecular Formula C18H18N2O3
Formula Weight 310.35
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TSU-68 (SU6668, Orantinib) is a potent inhibitor of Flk-1/KDR, FGFR1 and PDGFRβ with Ki of 2.1 μM, 1.2 μM, and 8 nM, respectively.
CAS No. 252916-29-3, 251356-54-4 (sodium salt)
Name: Sunitinib Malate (Sutent, SU11248)
Descriptions:
Product Number LS50026
CAS Number 341031-54-7
Product Name Sunitinib Malate (Sutent, SU11248)
Molecular Formula C22H27FN4O2.C4H6O5
Formula Weight 532.56
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Sunitinib Malate (Sutent, SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.
CAS No. 341031-54-7, 557795-19-4 (free base), 1126641-10-8 ( Maleic acid)
Synonyms SU-11248
Name: TAK-875
Descriptions:
Product Number LS50025
CAS Number 1000413-72-8
Product Name TAK-875
Molecular Formula C29H32O7S.1/2H2O
Formula Weight 533.63
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TAK-875 is a selective GPR40 agonist with EC50 of 14 nM.
CAS No. 1374598-80-7, 1000413-72-8 (free base)
Name: Temozolomide (Temozolomide, Temodar, Temodal)
Descriptions:
Product Number LS50024
CAS Number 85622-93-1
Product Name Temozolomide (Temozolomide, Temodar, Temodal)
Molecular Formula C6H6N6O2
Formula Weight 194.15
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Methazolastone (Temozolomide, Temodar, Temodal) is a DNA damage inducer.
Name: Tenofovir (Viread)
Descriptions:
Product Number LS50023
CAS Number 147127-20-6
Product Name Tenofovir (Viread)
Molecular Formula C9H14N5O4P
Formula Weight 287.21
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Tenofovir (Viread) is a drug used to treat human immunodeficiency virus (HIV) infection. Tenofovir is an antiviral drug called a nucleotide reverse transcriptase inhibitor. Tenofovir may reduce the amount of HIV in the blood and increase the number of CD4 cells (T-cells) in the blood. Tenofovir is used in combination with other drugs to treat the HIV virus. Tenofovir will not cure or prevent HIV infection or AIDS
CAS No. 147127-20-6, 206184-49-8 (H2O), 1236287-04-9 (Maleic acid)
Name: TGX-221 (TGX221)
Descriptions:
Product Number LS50022
CAS Number 663619-89-4
Product Name TGX-221 (TGX221)
Molecular Formula C21H24N4O2
Formula Weight 364.44
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TGX-221 is a potent, selective PI3K inhibitor for p110β with IC50 of 8.5 nM.
Name: Tigecycline
Descriptions:
Product Number LS50021
CAS Number 220620-09-7
Product Name Tigecycline
Molecular Formula C29H39N5O8
Formula Weight 585.65
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Tigecycline is a glycylcycline antibiotic. It was developed in response to the growing prevalence of antibiotic resistance in bacteria such as Staphylococcus aureus and acinetobacter baumanii.
CAS No. 220620-09-7, 197654-04-9 (HCl), 1135871-27-0 (methanesulfonate)
Synonyms Tygacil, GAR-936, WAY-GAR-936, TBG-MINO
Name: Tipifarnib (Zarnestra)
Descriptions:
Product Number LS50020
CAS Number 192185-72-1
Product Name Tipifarnib (Zarnestra)
Molecular Formula C27H22Cl2N4O
Formula Weight 489.40
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Tipifarnib (Zarnestra, R115777) is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM.
Name: Vandetanib (Zactima)
Descriptions:
Product Number LS50019
CAS Number 443913-73-3
Product Name Vandetanib (Zactima)
Molecular Formula C22H24BrFN4O2
Formula Weight 475.35
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Vandetanib (Zactima, ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM.
Name: Varenicline
Descriptions:
Product Number LS50018
CAS Number 249296-44-4
Product Name Varenicline
Molecular Formula C13H13N3
Formula Weight 211.26
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Varenicline is a prescription medication used to treat smoking addiction. Varenicline is a nicotinic receptor partial agonist. In this respect, it is similar to cytisine and different from the nicotinic antagonist, bupropion, and nicotine replacement therapies (NRTs) like nicotine patchesand nicotine gum. As a partial agonist, it both reduces cravings for and decreases the pleasurable effects of cigarettes and other tobacco products, and through these mechanisms it can assist some patients to quit smoking.
375815-87-5 (Varenicline tartrate), 249296-44-4 (free base), 230615-23-3 (HCl)
Name: Vicriviroc Malate
Descriptions:
Product Number LS50017
CAS Number 541503-81-5
Product Name Vicriviroc Malate
Molecular Formula C32H44F3N5O7
Formula Weight 667.72
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Vicriviroc (SCH-417690, SCH-D) is a potent CCR5 inhibitor with IC50 of 0.91 nM.
541503-48-4 (HCl), 306296-47-9 (free base)
Name: Voriconazole
Descriptions:
Product Number LS50016
CAS Number 137234-62-9
Product Name Voriconazole
Molecular Formula C16H14F3N5O
Formula Weight 349.31
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Voriconazole (VFEND) is a triazole antifungal medication that is generally used to treat serious, invasive fungal infections. These are generally seen in patients who are immunocompromised, and include invasive candidiasis, invasive aspergillosis, and certain emerging fungal infections.
Name: VX-222
Descriptions:
Product Number LS50015
CAS Number 1026785-59-0
Product Name VX-222
Molecular Formula C25H35NO4S
Formula Weight 445.61
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VX-222 (VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM.
Name: VX-702
Descriptions:
Product Number LS50014
CAS Number 479543-46-9
Product Name VX-702
Molecular Formula C19H12F4N4O2
Formula Weight 404.32
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VX-702 is a highly selective inhibitor of p38 MAPKα with IC50 of 4-20 nM.
Name: VX-745
Descriptions:
Product Number LS50013
CAS Number 209410-46-8
Product Name VX-745
Molecular Formula C19H9Cl2F2N3OS
Formula Weight 436.26
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VX-745 is a potent and selective inhibitor of p38α MAPK and p38β MAPK with IC50 of 10 nM and 220 nM, respectively.
Name: VX-809
Descriptions:
Product Number LS50012
CAS Number 936727-05-8
Product Name VX-809
Molecular Formula C24H18F2N2O5
Formula Weight 452.41
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VX-809 is a CFTR modulator with EC50 of 0.1 μM.
1160221-26-0 (HCl)
Name: WZ8040
Descriptions:
Product Number LS50011
CAS Number 1214265-57-2
Product Name WZ8040
Molecular Formula C24H25ClN6OS
Formula Weight 481.01
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WZ8040 is a novel mutant-selective irreversible EGFR T790M inhibitor.
Name: XL147 (SAR245408)
Descriptions:
Product Number LS50010
CAS Number 956958-53-5
Product Name XL147 (SAR245408)
Molecular Formula C21H16N6O2S2
Formula Weight 448.52
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Name: XL765
Descriptions:
Product Number LS50009
CAS Number 1123889-87-1
Product Name XL765
Molecular Formula C31H29N5O6S
Formula Weight 599.66
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XL765 is a dual inhibitor of mTOR/PI3k for mTOR, p110α, p110β, p110γ and p110δ with IC50 of 157 nM, 39 nM, 113 nM, 9 nM and 43 nM, respectively.
Name: Tigecycline
Descriptions:
Product Number LS50008
CAS Number 220620-09-7
Product Name Tigecycline
Molecular Formula C29H39N5O8
Formula Weight 585.65
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Tigecycline is a glycylcycline antibiotic. It was developed in response to the growing prevalence of antibiotic resistance in bacteria such as Staphylococcus aureus and acinetobacter baumanii.
197654-04-9 (HCl), 1135871-27-0 (methanesulfonate)
Synonyms Tygacil, GAR-936, WAY-GAR-936, TBG-MINO
Name: Ruxolitinib (INCB018424)
Descriptions:
Product Number LS50007
CAS Number 941678-49-5
Product Name Ruxolitinib (INCB018424)
Molecular Formula C17H18N6
Formula Weight 306.37
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INCB018424 (Ruxolitinib) is a JAK family inhibitor for JAK1, JAK2 and JAK3 with IC50 of 2.7 nM, 4.5 nM and 322 nM, respectively.
941678-50-8 (TFA), 1092939-15-5 (Maleic acid)
Name: Ibudilast
Descriptions:
Product Number LS50006
CAS Number 50847-11-5
Product Name Ibudilast
Molecular Formula C14H18N2O
Formula Weight 230.31
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Ibudilast is a potent PDE4 inhibitor for PDE4A with IC50 of 54 nM.
Name: VX-680
Descriptions:
Product Number LS50005
CAS Number 639089-54-6
Product Name VX-680
Molecular Formula C23H28N8OS
Formula Weight 464.59
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VX-680 (MK-0457, Tozasertib) is a pan-Aurora inhibitor of Aurora A, Aurora B and Aurora C with Ki (app) of 0.6 nM, 18 nM and 4.6 nM, respectively.
Name: ZSTK474
Descriptions:
Product Number LS50004
CAS Number 475110-96-4
Product Name ZSTK474
Molecular Formula C19H21F2N7O2
Formula Weight 417.41
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ZSTK474 (ZSTK-474) is a potent pan-class I PI3K inhibitor with IC50 of 37 nM.
Name: VX-950
Descriptions:
Product Number LS50003
CAS Number 402957-28-2
Product Name VX-950
Molecular Formula C36H53N7O6
Formula Weight 679.85
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Telaprevir (VX-950) is an HCV NS3-4A serine protease inhibitor with IC50 of 0.35 μM.
Name: PLX-4720
Descriptions:
Product Number LS50002
CAS Number 918505-84-7
Product Name PLX-4720
Molecular Formula C17H14ClF2N3O3S
Formula Weight 413.83
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PLX-4720 is a potent and selective inhibitor of B-Raf V600E and c-Raf-1 Y340D/Y341D with IC50 of 13 nM and 6.7 nM, respectively.
Name: AV-951
Descriptions:
Product Number LS50001
CAS Number 475108-18-0
Product Name AV-951
Molecular Formula C22H19ClN4O5
Formula Weight 454.86
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AV-951 (Tivozanib, KRN-951) is a potent and selective VEGFR inhibitor for VEGFR1/2/3 with IC50 of 0.21 nM/0.16 nM/0.24 nM and also inhibits PDGFR and c-Kit with IC50 of 1.72 nM and 1.63 nM, respectively.
Name: Cyclobutylmethyl bromide
Descriptions:
Product Number LS40121
CAS Number 17247-58-4
Product Name Cyclobutylmethyl bromide
Molecular Formula C5H9Br
Formula Weight 149.03
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Name: 3-Nitrophthalimide
Descriptions:
Product Number LS40120
CAS Number 603-62-3
Product Name 3-Nitrophthalimide
Molecular Formula C8H4N2O4
Formula Weight 192.13
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Name: 2-Tert-Butyl-5-chloro-1,1-dioxoisothiazol-3(2H)-one
Descriptions:
Product Number LS40119
CAS Number 850314-47-5
Product Name 2-Tert-Butyl-5-chloro-1,1-dioxoisothiazol-3(2H)-one
Molecular Formula C7H10ClNO3S
Formula Weight 223.68
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Name: N-Boc-N,N-bis(2-chloroethyl)amine
Descriptions:
Product Number LS40118
CAS Number 118753-70-1
Product Name N-Boc-N,N-bis(2-chloroethyl)amine
Molecular Formula C9H17Cl2NO2
Formula Weight 242.14
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