Name: Atazanavir sulfate(BMS-232632-05)
Descriptions:
Product Number LS50086
CAS Number 229975-97-7
Product Name Atazanavir sulfate(BMS-232632-05)
Molecular Formula C38H52N6O7.H2SO4
Formula Weight 802.93
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Atazanavir sulfate(BMS-232632-05) is a sulfate salt form of atazanavir (BMS-232632) that is an highly potent HIV protease inhibitor with an EC50 and EC90 of 2.6~5.3 nM and 9~15 nM in cell culture. Atazanavir (BMS-232632) is generally more potent than the five currently approved HIV-1 Prt inhibitors. Atazanavir (BMS-232632) inhibited the proteolytic cleavage of the viral gag precursor p55 polyprotein in a dose-dependent manner, with a EC50 of approximately 47 nM. Furthermore, Atazanavir (BMS-232632) is highly selective for HIV-1 Prt and exhibits cytotoxicity only at concentrations 6,500- to 23,000-fold higher than that required for anti-HIV activity. Atazanavir (BMS-232632) may be an effective HIV-1 inhibitor that may be utilized in a variety of different drug combinations.
Synonyms BMS-232632-05, Reyataz
CAS No. 229975-97-7 198904-31-3
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